Global Cambridge in Kuala Lumpur
The changing face of medicine
Hear your host Vice-Chancellor, Professor Stephen J Toope (Trinity 1983), and two very different Cambridge researchers, each at the cutting-edge of their fields.
Professor Andrew McCaskie, a Professor of Orthopaedic Surgery and Head of the Department of Surgery, is at the forefront of moves to make us move more – and to find innovative ways to avoid surgery through prevention and treatment of osteoarthritis before it reaches critical stages. Dr Serena Nik-Zainal (Murray Edwards 1995), a CRUK Advanced Clinician Scientist and Honorary Consultant in Clinical Genetics, uses next-generation genetic sequencing to locate patterns in cancer, allowing for early detection and more effective targeted treatment.
Together they will discuss the changing face of medicine: from moving more to mapping the human genome.
Professor Stephen J Toope
Professor Stephen J Toope became the 346th Vice-Chancellor of the University of Cambridge in 2017. Previously Director of the Munk School of Global Affairs at the University of Toronto and President and Vice-Chancellor of the University of British Columbia, he is a former President of the Pierre Elliott Trudeau Foundation and Dean of Law at McGill University. He has served as Chair of the Board of Universities Canada, President of the Federation for the Humanities and Social Sciences, and as Director of the Public Policy Forum, the Canadian Institute for Advanced Research and the Royal Conservatory of Music.
Professor Toope is an expert on international dispute resolution, international environmental law, human rights, the use of force, and international legal theory. He is writing with Professor Jutta Brunnée exploring mechanisms and processes fostering stability and change in international law. He has served as Chair of the United Nations Working Group on Enforced and Involuntary Disappearances, and as Fact-Finder for the Commission of Inquiry into the Actions of Canadian Government Officials in relation to Maher Arar.
Professor Andrew McCaskie MB ChB MMus MD FRCS FRCS (T&O)
Professor McCaskie is Professor of Orthopaedic Surgery and Head of the Department of Surgery.
He is the Director of the Arthritis Research UK Tissue Engineering Centre, which brings together leading clinicians, engineers and biologists from research and clinical groups from universities across the UK to develop regenerative therapies for people with Osteoarthritis.
Professor McCaskie led the Smart Step programme as part of Stage II UK Regenerative Medicine Platform and is a co-investigator in the recently established UK Regenerative Medicine Platform: Engineered cell environment. The overarching aim is to develop innovative therapies for musculoskeletal disease, particularly in osteoarthritis, which affects around eight million people in the UK alone.
Professor McCaskie has been President of the British Orthopaedic Research Society, member of the Council of Management of The British Editorial Society of Bone and Joint Surgery, and member of Council of the British Orthopaedic Association. He is one of the three editors of Bailey and Love's Short Practice of Surgery (27th edition) and is the Director of the Academic Foundation Programme in Cambridge and initiated the transplant and regeneration theme.
He now leads an emerging initiative to advance musculoskeletal care by considering the importance of movement in both health and disease, based around a research hospital concept: Cambridge Movement Centre.
Dr Serena Nik-Zainal MD PhD
Following a first-class basic degree in preclinical science, Dr Serena Nik-Zainal obtained a medical degree from the University of Cambridge, sponsored by Petroliam Nasional Berhad Malaysia (PETRONAS) and as a Fellow of the Cambridge Commonwealth Trust. She trained in general internal medicine before specialising in Clinical Genetics. Serena has been an Honorary Consultant in Clinical Genetics at the Cambridge University Hospitals NHS Foundation Trust since February 2013.
Serena undertook a PhD at the Wellcome Trust Sanger Institute (WTSI), exploring cancer using next-generation sequencing (NGS) technology. She was heavily involved in the development of the whole genome sequencing (WGS) data processing pipeline for human cancers. Armed with WGS data, she pioneered a multitude of analytical principles to reveal underlying abnormal biology of tumours. Serena led the production and analysis of the largest cohort of whole genome sequenced cancers of a single tissue type to date, of 560 breast cancers. In parallel, she has been exploring the causes of mutational signatures whether environmental or cell-intrinsic, using human induced pluripotent stem cell (iPSC) systems.
Now based at University of Cambridge at the MRC Cancer Unit and the Department of Medical Genetics, Serena is determined to advance the field of mutational signatures through a combination of computational and experimental approaches, to create clinical applications.
The nearest stations to the W Hotel are Bukit Nanas monorail station (line 8) and KLCC LRT station (Kelana Jaya line).
Directions by car are available on the W Kuala Lumpur's website.